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Participants receiving the highest dose (12 mg weekly) achieved a mean body weight reduction of approximately 24% from baseline at 48 weeks — a figure that, whilst encouraging, should be interpreted with caution as cross-trial comparisons with approved agents are not methodologically robust in the absence of head-to-head data

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The MASH trials’ main goals are to improve liver fibrosis and resolve steatohepatitis without worsening either condition in people with MASH